Efficacy and Durability of High-Frequency Repetitive Transcranial Magnetic Stimulation Targeting the Left Dorsolateral Prefrontal Cortex in Treatment-Resistant Major Depressive Disorder: A Randomized, Sham-Controlled Trial with 6-Month Follow-Up
Importance: Treatment-resistant major depressive disorder (TRD) affects approximately one-third of patients with MDD and is associated with profound functional disability and excess mortality. High-frequency rTMS has regulatory approval for MDD but its specific efficacy in rigorously defined TRD, co...
treatment-resistant depressionrepetitive transcranial magnetic stimulationDLPFCneuromodulation